Results
| PMID | 25443469 |
| Gene Name | GSTM1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 5803 |
| Population details | 5803 (2,684 endometriosis cases, 3,119 control cases) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
J Gynecol Obstet Biol Reprod (Paris). 2015 Feb;44(2):136-44. doi: Li, H| Zhang, Y Department of Gynaecology, Shi Jia Zhuang the Third Hospital, Shi Jia Zhuang 050011, China.| Reproductive Medicine Center, Zhongnan Hospital, Wuhan University, 169, Donghu Road, Hubei Province, Wuhan 430071, China. Electronic address: yuanzhenzhang62@ BACKGROUND: Many studies have investigated the association between glutathione S-transferase M1 (GSTM1) null genotype and the risk of endometriosis. However, the effect of the GSTM1 null genotype on endometriosis is still unclear because of apparent inconsistencies among those studies. A meta-analysis was performed to characterize the relationship more accurately. PubMed, Embase, and Web of Science were searched. OBJECTIVE: To derive a more precise estimation of the relationship, a meta-analysis was performed. METHODS: We estimated the summary odds ratio (OR) with a 95% confidence interval (95% CI) to assess the association. Up to 24 case-control studies with 2,684 endometriosis cases and 3,119 control cases were included into this meta-analysis. RESULTS: Meta-analysis of the 24 studies showed that GSTM1 null genotype was associated with the risk of endometriosis (random effects OR=1.66, 95% CI 1.23 to 2.24). In the subgroup analysis by ethnicity, increased risks were found for both Caucasians (OR=1.26, 95% CI 1.04-1.51) and Asians (OR=1.28, 95% CI 1.06-1.55). No evidence of publication bias was observed. CONCLUSION: In conclusion, this meta-analysis suggests that the GSTM1 null genotype increases the overall risk of endometriosis. Mesh Terms: Adolescent| Adult| Case-Control Studies| Endometriosis/epidemiology/*genetics| Female| Genetic Predisposition to Disease| Genotype| Glutathione Transferase/*genetics| Humans| Middle Aged| *Polymorphism, Genetic| Young Adult|DA 2015/11/18 06:00 |
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